NHS Ayrshire and Arran Chief Executive John Burns is stepping down from his role.
Mr Burns will end his nine years in his Chief Executive role to become chief operating officer of Health and Social Care NHS Scotland.
Nurse director and deputy chief executive, professor Hazel Borland, will act as Interim chief executive during the recruitment period.
Board chairperson, Lesley Bowie, said: "After nine years in the role of chief executive John is moving on to take up a fresh opportunity.
"NHS Scotland’s gain will be a huge loss for NHS Ayrshire & Arran, however I wish to thank John for his leadership and dedication to our health board over the years and offer him congratulations in his new appointment and every success in his new endeavour."
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