The hotly anticipated clash is scheduled for Saturday, September 29.
Girvan host Culter and Whitletts Vics host Lanar Unied.
Irvine Vics will host Kirkintilloch Rob Roy and Irvine Meadow will be favoured to come through away to St Anthony's.
Maybole are at home to Aberdeen University.
The full draw for the Macron Scottish Junior Cup, affecting Ayrshire teams is, as follows:
Kinnoull v Saltcoats Victoria
Troon v Lochee Harp
Auchinleck Talbot v Forfar West End
Cumnock v Coupar Angus
Cumbernauld United v Glenafton Athletic
Girvan v Culter
Muirkirk v Yoker Athletic
Gartcairn v Kilbirnie Ladeside
Bridge of Don Thistle v Ardrossan Winton Rovers
Maybole v Aberdeen University
Kilwinning Rangers v Beith
Hurlford United v Dufftown
Lochee United v Dalry Thistle
St Anthony's v Irvine Meadow
Irvine Victoria v Kirkintilloch Rob Roy
Petershill v Darvel
Royal Albert v Lugar Boswell Thistle
Annbank United v Ardeer Thistle
Arbroath Victoria v Largs Thistle
Bathgate Thistle v Craigmark Burntonians
Kello Rovers v Blairgowrie
Whitletts Victoria v Lanark United
Comments: Our rules
We want our comments to be a lively and valuable part of our community - a place where readers can debate and engage with the most important local issues. The ability to comment on our stories is a privilege, not a right, however, and that privilege may be withdrawn if it is abused or misused.
Please report any comments that break our rules.
Read the rules hereComments are closed on this article